Full Name
B. Duygu 脰zpolat
Title
Hibbitt Fellow
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- ORCID ID:
0000-0002-1900-965X
BS, Biology, Middle East Technical University, 2004
Reproductive cells are the cells that become eggs and sperm, and then have the potential to give rise to a whole organism.听Many organisms (such as hydra, flatworms, earth worms, or sea stars) regenerate their reproductive organs and reproductive cells as a part of whole body regeneration. In contrast, humans and well-established research organisms lack this ability. The mechanisms of regenerating the reproductive cells are not understood but is one of the most impactful regeneration abilities. Understanding the mechanisms of regenerating this cell type would provide insight into the 鈥渕other of all stem cells鈥. The goal of our laboratory is to close this knowledge gap and define the cellular origins and molecular mechanisms of germ cell regeneration. What are the embryonic origins of cells involved in reproductive cell regeneration? Can any cell type regenerate reproductive cells, or are there limitations to which cells can replace them? How is the genome integrity maintained in regenerated reproductive cells?
To answer these questions, we combine many exciting techniques such as live-imaging, genome-editing, mRNA injections, and transgenesis. We use marine and aquatic segmented worms such as Dumeril's clam worm (), and the water nymph worm (Pristina leidyi).
(in press, JEZ-B) Kuehn E., Clausen D., Null R.W., Metzger B., Willis A.,聽脰zpolat B.D.听Segment number threshold determines juvenile onset of germline cluster expansion in聽Platynereis dumerilii听(2021)听
脰zpolat B.D., Randel N., Williams E.A., Bezares-Calder贸n L.A., Andreatta G., Balavoine G., Bertucci P., Ferrier D., Gambi M.C., Gazave E., Handberg-Thorsager M., Hardege J., Hird C., Hsieh Y., Hui J., Mutemi K.N., Schneider S.Q., Simakov O., Vergara H., Vervoort M., J茅kely G., Tessmar-Raible K., Raible F., Arendt D.听 [EvoDevo%2012,%2010%20(2021).%20https%3A//doi.org/10.1186/s13227-021-00180-3]The nereid on the rise: Platynereis as a model system.听EvoDevo 12, 10 (2021) (Emerging Systems Series)
Torres J.P., Lin Z., Watkins M., Salcedo P.F., Baskin R.P., Elhabian S., Safavi-Hemami H., Tun J., Saguil N., Fang Y., Urdaneta R.F.,聽脰zpolat B.D., Olivera B.M., Schmid E.W. Small molecule mimicry hunting strategy in the imperial cone snail,聽Conus imperialis. (2021)聽聽12 Mar 2021: Vol. 7, no. 11
Kuehn E., Girard J., Stockinger A., Raible F.,聽脰zpolat B.D.聽A scalable culturing system for the marine annelid聽Platynereis dumerilii.听听(2019)
脰zpolat B.D., Handberg-Thorsager M., Vervoort M., Balavoine G. Cell lineage and cell cycling analyses of the 4d micromere using live imaging in the marine annelid聽Platynereis dumerilii.听聽DOI: 10.7554/eLife.30463 (2017)聽
脰zpolat B.D., Sloane E., Zattara E.E.,聽Bely A.E. Plasticity and regeneration of gonads in the annelid聽Pristina leidyi. 聽. (2016)
脰zpolat B.D., Bely A.E.聽Developmental and molecular biology of annelid regeneration: a comparative review of recent studies.听. (2016)聽(Review)
脰zpolat B.D., Bely A.E.. Gonad establishment during asexual reproduction in the annelid聽Pristina leidyi.听405(1):123鈥36. (2015)聽